Liu Yi
Sichuan University School of Medicine, China
Title: Effects of combined oral sucrose and non-nutritive sucking (NNS) on procedural pain of NICU newborns, 2001-2016: A systematic review and meta-analysis
Biography
Biography: Liu Yi
Abstract
The purpose of this study was to evaluate the efficiency of combined oral sucrose and non-nutritive sucking (NNS) on pain relief in NICU newborns when undergoing painful procedures. We have searched PubMed, Ovid (Medline), Embase (Medline), Cochrane Central Library, and other resources such as Google Scholar, bibliographies of included literatures for all available articles; two reviewers screened literatures and extracted data independently. Then, the fixed effects model was performed for pooling the results by using Reviewer Manager (RevMan) 5.3.
A total of 7 randomized controlled trials (RCTs), including 599 participants, were contained in our meta-analysis. This meta-analysis suggested that the combination of oral sucrose and NNS is associated with reduced pain scores (mean difference [MD], -0.52; 95% confidence interval [CI], -0.68 to -0.36);shorten crying time (MD,-0.92; 95% CI,-1.39 to -0.44);but there is no difference between two groups in reducing bradycardia (MD, 0.73; 95% CI, 0.32 to 1.68), tachycardia (MD, 0.65; 95% CI, 0.38 to 1.10), and desaturations (MD, 0.73; 95% CI, 0.32 to 1.68) . The pooled evidence indicates that the combination measures should be considered as an evidence-based guideline for pain relief undergoing minor painful. Besides, it also indicates that OS+NNS can be an alternative for better prevention and management of procedures pain in NICU newborns. However, the results may impaired due to data were uncompleted, and thus, more RCTs or well-designed studies are required to detect the effects of OS+NNS in the further.