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6th World Nursing and Healthcare Conference

London, UK

Aslam Pathan

Aslam Pathan

Shaqra University, Saudi Arabia

Title: In vivo neurological assessment of serotonergic response of Coriandrum sativum L. seeds in mice

Biography

Biography: Aslam Pathan

Abstract

Ethnopharmacological relevance: seeds of Coriandrum sativum L. have been used in the Indian traditional medicine to relieve stress and other neurological disease conditions. Aim of the study: The present study was under taken to evaluate the anxiolytic effects of seeds of Coriandrum sativum L. Ethanolic Extract (CSEE) in mice. Materials and methods: seeds of Coriandrum sativum L. Ethanolic extract was screened for anxiolytic effect by using Rota rod test, Open field test and Hole board test at doses of 100 and 200 mg/kg. Distilled water and Diazepam were employed as negative and positive control groups, respectively. Results: anxiolytic like activity assessment of seeds of Coriandrum sativum L. Ethanolic Extract (CSEE) 200 mg/kg by using rota rod test shows significantly decrease in performance time (124) as compared to standard (110) and control (150) treatment group. While open field test of seeds of Coriandrum sativum L. Ethanolic Extract (CSEE) 200 mg/kg shows significantly decrease in number of square crossing (21) as compared to standard (15) and control (28) treatment group. Hole board test of seeds of Coriandrum sativum L. Ethanolic Extract (CSEE) 200 mg/kg shows significantly decrease in number of head dipping (09) as compared to standard (07) and control (14) treatment group Conclusion: The results of this study established a support for the traditional usage of seeds of Coriandrum sativum L. as anxiolytic medicinal plant.