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To determine the efficacy of different methods of cardiopulmonary resuscitation (CPCR) training in nurse personnel. In a prospective and observational study of 150 individuals in nurse personnel 4 different protocols of CPCR training were applied and their efficacy was investigated. Also, 12 months after the study course, 60 participants were asked to take apart in a theoretical and practical examination to evaluate the long-term efficacy of the 4 protocols. Nurse personnel with more duration of special work time obtained more scores. Also individuals with history of CPCR training in other courses were more successful. Comparison of different methods of CPCR learning showed that the workshop using interactive lecture as well as human model, educational film, and reference CPCR book has the highest efficacy in all groups. This protocol of CPCR training showed more efficacy in long-term post-delayed evaluation. This course also increased confidence for doing CPCR in nurse personnel.